Sensilun

what is the case of diabetes, and what are the best medication to be used,can it be managed,if so for how long?

please let me know as soon as possible,thank you.simon audi.

Causes of DIABETES

There are many causes of diabetes. Not all people have control of whether they could have prevented the disease. Eating healthy is a big factor in prevention, but some times that’s not enough. Below are several ways it can be caused.

The disease is caused when the pancreas becomes dysfunctional. The body is dependent upon the insulin the pancreas secretes to keep the body’s blood sugar levels normal. Many things can cause the pancreas to become dysfunctional and cause illness.

Diabetes is known to be higher in certain ethnicities such as Asian American, Hispanic, African American, Native American and Pacific Island descendants. The disease is known to be inherited and if it runs in your family, then you have a 25% chance of having it eventually.

Age is a big cause because as people get older, they exercise less and they gain weight, causing the body’s pancreas to improperly secrete insulin. It can also be caused by a viral infection or illness affecting the pancreas, causing it not to secrete insulin properly.

However, the biggest cause is obesity. Excessive weight and fat in the body cause muscle and tissues not to react to insulin the way they should, almost making them resistant to the insulin the pancreas is secreting. The insulin will not function properly causing high blood sugar levels, eventually leading to the disease. Overeating can cause it also. The body needs a proper balance in its diet and if a body has too many carbohydrates, fats, or proteins, it can cause the pancreas to be dysfunctional also.

Frequent smoking can eventually lead to diabetes. Stress is also a major factor. The body’s metabolism is directly influenced by its lifestyle. This includes the amount of daily stress; grief, and excessive worrying, that can cause the metabolism to react differently to insulin and the person to become a diabetic.

The body needs plenty of exercise and a balanced diet for the pancreas to properly function, secreting enough insulin. Many people cannot prevent this disease, especially if they inherit the disease or contract a viral infection causing it. The causes of diabetes vary, but the most important thing in trying to prevent it are maintaining a healthy lifestyle with plenty of exercise and eating right.

For type 1 , Insulin is in order .
For type 2 Metformin is the oldest and most effective drug.
Never ever take Actos or Avandia. They may kill you. Bone fractures, heart problems and what diabetics really don’t need is that they change Bone Stem Cells to Fat Cells.And to top that off , blindness is also associated with both drugs..

Good Luck

Tin

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Effect of diabetes medication on Kidney function (GFR)?

I don’t know if this is too technical but I’ll give it a go…

My grandmother, who is 87 yrs old and a diabetic (Type 2), is in Stage 5 with a GFR that is now below 10. When she was officially told that she was at this stage about 1yr ago, the GFR was at 10.5 and remained at that level for a few months. But here is the confusing part. She has been on Diamicron (aka. gliclazide – diabetes medication) for a number of years until about 7 months ago when she ran out and the prescription was not renewed. When she went for her tests two months after stopping the medication, the GFR was at 13. The following month it was up to 19. Initially we thought the medication might have had something to do with the decreasing GFR. We asked the doctors about a possible correlation but they told us that there was no link. Yet, when we look at the description for Diamicron, it clearly states that people who have impaired kidney function should NOT take this medication. Of course her glucose levels went up without the Diamicron and a little over a month ago she was put back on the medication. Two weeks ago she went in for another set of blood tests and lo and behold, the GFR had plunged from the previous 19 to 8.4. I can’t help but think that this fluctuation in GFR is more than just pure coincidence. Does anybody here have any insight on the role that diabetes medication plays in GFR calculation or if it truly has an impact on the results. And if there is a link, is there another way of treating the diabetes that will not further reduce kidney function?
P.S. She is currently not on dialysis and probably won’t be. Interestingly enough, potassium, sodium, phosphorous are all in the normal range and she is passing urine with negligible change in frequency and colour.
Unfortunately I’m not in my home country @ the moment, but I can say that this diabetes medication was and still is successful in controlling her glucose levels. When she was off it; her levels went up to 8.9 from 4.7. Her blood pressure is also under control but I’m not sure what she was taking for that. She is also taking epo. injections every 3 weeks for anemia. Her appetite is poor, but has been like this for a while now, and consequently she has lost a significant amount of weight. She has a whole host of medications but of course I don’t have access to that information now. What I find curious though is that two years ago, the blood tests showed a GFR of 20, but this didn’t seem to alarm the diabetes specialist at all. Only when it went down to below 15 was she referred to a renal management clinic run by the same doctor who was treating her hypertension. Even with this supposed 8.4 GFR there is no real sense of urgency – potassium, sodium, urea, phosphorous – all normal.
Cardiac markers are high but a stress test was perfectly normal even though she does have angina attacks which has been a long-standing problem as well as attacks of vertigo which has also been long-standing. The creatinine is @ 3.3-3.4 mg/dL now…a slight rise after two previous tests -notably those when she was off the diabetes medication – had shown a decrease.

You are correct that oral sulfonylureic agents should not be used in individuals with diabetic nephropathy. In fact I do not use these medications at all as they lead to premature pancreatic beta cell failure committing individuals to insulin. There is insufficient information for me to be able to offer an opinion as to whether or not this medication played a role in her decreasing renal function. You do not tell me what her medical regimen is now nor do you offer insight into her level of diabetic control. Reference laboratories have adopted the pernicious habit of calculating the GFR. These calculations have no predictive validity as they do not correlate with true renal function. To truly measure glomerular filtration rate a person must collect their urine for 24 hours and blood work is done when the urine is dropped off. If her GFR was not determined in this way then there would be no way to make sense of the GFR readings. If her GFR is truly at 8.4 then I would not be too quick to say that she will never need dialysis. If I may be of further assistance please let me know. I wish you both the very best of health and in all things may God bless.

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Is anyone on the new medication for diabetes called Januvia? Anyone have good results?

Januvia is not all that new! It has been available for about 5 years now. I was already on insulins when it came out so I didn’t even get to try it to see if it would help. Several E-friends have been on it and had good to excellent results. Weight loss combined with good glucose control.

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ive got type one diabetes take medication for high blood pressure?

but my pulse rate is normally one hundred thats when im relaxing im totally unfit and two stone over weight, im really consirned and stupid i know because im frightened to go to the doctors with this problem as i think im proberly being daft but i can feel my heart beating even when im relaxing you would think id ran a mile it beats so hard you can see my chest moving it dosnt feel normal has anyone had this problem.

Kathleen’s answer was unkind and her comment regarding amlodipine besylate (Norvasc) uncalled for. Yes it may cause swelling but it does so infrequently. That having been said amlodipine is not my 1st 2nd or 3rd choice for treating hypertension. The resting pulse has traditionally been stated to be 60 to 100 but by 1990 24 hour ambulatory blood pressure and pulse studies had redefined this as 50 to 90. You do not give your age and younger people tend to run higher pulses. Assuming that you are age 25 or older then a consistent resting pulse of 100 would certainly get my attention. High blood pressure increases your risk of cardiovascular events but an elevated pulse places an increased work-load on the heart and adds to this risk. Most people with elevated pulse rates have an increase in what is known as adrenergic tone which means an imbalance in the two main components of our nervous system. The treatment is usually to make use of a beta blocker such as atenolol or metoprolol tartrate. These are perfectly safe for a diabetic to take. Nonetheless only your physician will be able to determine whether or not you should be on a beta blocker. Typically the physician will perform an electrocardiogram. This records only 10 seconds of the heart’s activity so on occasion the physician will request a 24 hour Holter monitor. If I may be of further assistance please let me know. I wish you the very best of health and may God bless. [If I recall correctly 2 stones means 28 pounds. You do not give your age, gender, height and weight. If your body mass index - weight in kilograms divided by height in meters squared - is over 30 this may be a factor in both diabetic control and pulse. Again - please discuss this with your physician. If you type 'body mass index' into any search engine you will find multiple sites that will calculate your BMI for you for free.]

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I have a question about diabetes and medication?

i have been prescribed metformin for my diabetes and the doctor wants to prescribe a cholesterol lower drug called statins but i don’t have high cholesterol but the doctors said that it will stop me from having a heart attack so how does that work? And i am also on blood pressure medication which is supposed to prevent me from having a heart attack/stroke and i don’t understand this, how does this work?

I refused to take the cholesterol medication because i do not suffer from high cholesterol.
do you know the risks if i don’t go on the cholesterol medication

You have got diabetes and hypertension. So the chances of heart attack, stroke or kidney failure are several times higher. Since you are a diabetic, you should be considered as a heart patient even if you did not have any heart attack in the past.

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